Ezogabine skin discoloration is reversible after discontinuation
نویسندگان
چکیده
There is concern that bluish skin discoloration associated with ezogabine treatment could be permanent. We present a case of ezogabine-induced skin discoloration that resolved completely after discontinuation. A 55-year-old woman started ezogabine 400 mg three times a day at age 41. Bluish pigmentation over the toe nails, finger nails, around eyes and over and around lips was first noted after 5 years of treatment. Ezogabine was discontinued eight years after initiation. Skin discoloration improved within 6 months and completely resolved within 6 years of discontinuation. This case suggests that ezogabine-induced discoloration is reversible after discontinuation of treatment.
منابع مشابه
Blue-gray mucocutaneous discoloration: a new adverse effect of ezogabine.
IMPORTANCE Many drugs have been reported to induce skin and/or mucous membrane discoloration. Ezogabine (retigabine) was recently approved as an add-on drug for the treatment of partial seizures in adults with epilepsy. Mucocutaneous discoloration induced by antiepileptic drugs in general and ezogabine in particular has not been previously reported. OBSERVATIONS Two patients who had received ...
متن کاملReversible Teeth Discoloration in Children: A Linezolid Therapy Side Effect.
To the Editor: A 9-year-old girl was admitted with surgical-site infection after triple pelvic osteotomy. Superficial wound exudate culture yielded methicillin-resistant Staphylococcus aureus (MRSA). Ultrasound revealed a soft tissue heterogeneous collection with subcutaneous fistulization. She completed 14 days of intravenous vancomycin and gentamicin with clinical and laboratory improvement. ...
متن کاملEfficacy of Retigabine in Adjunctive Treatment of Partial Onset Seizures in Adults
OBJECTIVE To evaluate efficacy and tolerability of retigabine (ezogabine, US adopted name) in the adjunctive treatment of partial-onset seizures in adults. Retigabine is the first anticonvulsant in its class, decreasing neuronal excitability by opening voltage-gated potassium channels. METHODS MEDLINE and EMBASE were systematically searched using search terms retigabine and ezogabine for rand...
متن کاملDiscoloration of nail beds and skin from minocycline.
224 CMAJ, February 8, 2011, 183(2) © 2011 Canadian Medical Association or its licensors A49-year-old man presented with “bruising” of the fingernails and facial skin. He had recalcitrant rosacea and had undergone bilateral cataract extraction, but had no other significant medical history. He had not no ticed a propensity to bruise, impairment of wound healing or any excessive gingival or nasal ...
متن کاملبررسی تأثیر طول مدت تزریق هپارین زیر جلدی بر وسعت کبودی محل تزریق بیماران بستری در بیمارستانهای قلب حضرت فاطمه(س) و شهید بهشتی شیراز در سال 1381
Introduction: Heparin is only fast acting anticoagulant drug available in the injectable form. Skin discoloration is an adverse and unpleasant outcome of subcutaneous heparin injection that is observed frequently and causes the patient both physical and psychological discomfort thus limiting the further sites for injection. It is therefore important that nurses use an injection technique that m...
متن کامل